Sustainable Weight Loss
Achieve lasting results with 12-15% average weight loss maintained over time
Cardiovascular Protection
Reduces risk of major cardiovascular events by 20%
Multiple Forms Available
Choose between weekly injection or daily oral tablet for your lifestyle
Why Semaglutide is Your Weight Loss Solution
Semaglutide is a groundbreaking glucagon-like peptide-1 (GLP-1) receptor agonist that has revolutionized weight management and diabetes treatment. Originally developed for type 2 diabetes, its remarkable weight loss effects have made it the go-to choice for sustainable, medically-supervised weight management.
Mechanism of Action
- Insulin Secretion: Stimulates glucose-dependent insulin release from pancreatic beta cells
- Glucagon Suppression: Reduces glucagon secretion from pancreatic alpha cells when glucose levels are elevated
- Gastric Emptying: Slows gastric emptying, promoting satiety and reducing post-meal glucose spikes
- Central Appetite Control: Acts on hypothalamic receptors to reduce appetite and food intake
- Beta Cell Preservation: May help preserve pancreatic beta cell function
Life-Changing Benefits
Diabetes Benefits:
- HbA1c reduction of 1.0-1.8%
- Reduced fasting glucose levels
- Lower postprandial glucose excursions
- Cardiovascular risk reduction
- Low hypoglycemia risk
Weight Management Success:
- Average weight loss of 12-15% in clinical trials
- Sustained weight reduction over 68 weeks
- Improved body composition
- Reduced visceral adiposity
- Better weight maintenance
Dosing and Administration
Injectable Form:
Route: Subcutaneous injection once weekly
Starting Dose: 0.25 mg once weekly for 4 weeks
Dose Escalation:
- 0.5 mg once weekly (weeks 5-8)
- 1.0 mg once weekly (maintenance for diabetes)
- 1.7 mg once weekly
- 2.4 mg once weekly (weight management dose)
Oral Form:
Route: Oral tablet once daily
Starting Dose: 3 mg once daily for 30 days
Maintenance: 7 mg or 14 mg once daily
Administration: Take on empty stomach with ≤4 oz water, 30 minutes before first food/drink/medication of the day
Side Effects
Common (≥5%):
- Nausea (15-20%)
- Vomiting (5-9%)
- Diarrhea (8-9%)
- Abdominal pain (5-7%)
- Constipation (3-7%)
- Headache (5-6%)
- Fatigue (3-5%)
Serious (Rare):
- Acute pancreatitis
- Gallbladder disease
- Acute kidney injury
- Diabetic retinopathy complications
- Severe hypoglycemia (with insulin/sulfonylureas)
- Thyroid C-cell tumors (animal studies)
Drug Interactions
- Insulin and Insulin Secretagogues: Increased risk of hypoglycemia; dose reduction may be needed
- Oral Medications: May delay absorption due to delayed gastric emptying
- Warfarin: Monitor INR more frequently when initiating semaglutide
- Oral Contraceptives: Use alternative contraceptive method for 4 weeks after starting or dose increases
Monitoring Parameters
- Blood Glucose: Regular monitoring, especially when combined with other diabetes medications
- HbA1c: Every 3-6 months
- Weight and BMI: Regular monitoring for weight management indication
- Renal Function: Baseline and periodic monitoring
- Signs of Pancreatitis: Educate patients on symptoms
- Diabetic Retinopathy: Regular ophthalmologic examinations
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