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PT141 (Bremelanotide)

PT141 (Bremelanotide)

What is PT-141?

PT-141, also known as Bremelanotide in its generic clinical name, represents a heavily modified synthetic derivative of alpha-melanocyte-stimulating hormone. In clinical trials, it has been examined as a potential treatment for a lack of sexual desire in both males and females. This synthetic peptide acts as an agonist for the melanocortin-4 (MC-4R) and melanocortin-1 (MC-1R) receptors.

The primary focus of PT-141 revolves around its ability to promote sexual arousal. The peptide's mechanism involves binding primarily to the MC-4R and MC-1R, which are implicated in the regulation of sexual function.

Research suggests that PT-141's agonistic action on melanocortin receptors extends beyond sexual arousal, with implications for its involvement in immune system stimulation. This multifaceted nature positions PT-141 as a peptide with diverse therapeutic potential.

Derived from melanotan 2 (MT-2), PT-141 inherits its lineage from synthetic melanocortins. The exploration of PT-141's various applications underscores its significance in addressing both physiological and clinical challenges.

 

What Are the Effects of PT-141?

Stimulates Sexual Arousal

PT-141, also known as Bremelanotide, has been studied for its ability to stimulate sexual arousal in both males and females. As an agonist for the melanocortin-4 receptor (MC-4R) and melanocortin-1 receptor (MC-1R), PT-141 influences the central nervous system, particularly the pathways related to sexual response. Research of PT-141 demonstrated its potential as a treatment for a lack of sexual desire. The peptide's action involves activating melanocortin receptors, which play a role in the regulation of sexual function, and it has shown promise in addressing sexual dysfunction by promoting sexual arousal.

Stimulates the Immune System

Beyond its effects on sexual arousal, PT-141 has also been found to stimulate the immune system. The melanocortin receptors, particularly MC-1R, are known to modulate immune responses. Research suggests that PT-141's interaction with these receptors may have immunomodulatory effects, influencing the body's immune function. While the exact mechanisms and clinical implications of its impact on the immune system are still areas of ongoing study, the dual action of PT-141 on both sexual arousal and immune response makes it a subject of interest in various medical contexts.


Chemical Structure of PT-141 

The specific chemical structure of PT-141 involves a modified synthetic derivative of alpha-melanocyte-stimulating hormone (α-MSH). The chemical structure of PT-141 consists of a chain of amino acids. The sequence is as follows:

AC-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH

This sequence plays a key role in the peptide's ability to interact with specific receptors in the body.

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