Gonadorelin Acetate

What is Gonadorelin?

Gonadorelin is a synthetic decapeptide analogue of endogenous gonadotropin-releasing hormone (GnRH), identical in sequence to the naturally occurring hormone produced by the hypothalamus. In laboratory research, it is used to stimulate the anterior pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), enabling controlled investigation into neuroendocrine and reproductive signaling pathways.

Chemical Structure of Gonadorelin

The peptide sequence is pGlu–His–Trp–Ser–Tyr–Gly–Leu–Arg–Pro–Gly–NH₂, with a chemical formula of C₅₅H₇₅N₁₇O₁₃ and an average molecular weight of approximately 1,182 Da. As a ten-amino acid peptide with a pyroglutamate residue at the N-terminus and amidated C-terminus, Gonadorelin displays rapid pharmacokinetics, with an elimination half-life of 10–40 minutes in circulating research models.

What Are the Effects of Gonadorelin?

• Pituitary Gonadotropin Release: Stimulates synthesis and secretion of LH and FSH in vitro and in vivo via activation of GnRH receptors, facilitating controlled experimental modulation of the HPG axis.
• Pulsatile Secretion Modeling: Due to its short half-life, Gonadorelin requires pulsatile or repeated dosing to mimic physiological GnRH pulses, a property leveraged in research protocols.
• Reproductive Endocrine Studies: Extensively utilized to examine reproductive hormone dynamics, including studies on ovulation induction, testosterone regulation, and fertility signaling in diverse mammalian models.
• Endocrine Feedback Investigations: Serves as a tool to study negative feedback loops involving sex steroids and inhibin, particularly in models of endocrine disorders and aging.
• Cancer Research Application: In laboratory models such as hormone-responsive prostate cancer cell lines, GnRH receptor-targeted agents like Gonadorelin are being explored for selective cellular targeting and antiproliferative activity.