GHRP-2, also known as pralmorelin, is a synthetic growth hormone secretagogue recognized for its binding affinity to the ghrelin/growth hormone secretagogue receptor. It stands as the pioneering compound among growth hormone secretagogues and currently serves as a test peptide for evaluating growth hormone deficiency and secondary adrenal failure. Positioned for stage II clinical trials, GHRP-2 is being explored for assessing short stature and is actively under investigation for its potential impacts on appetite, muscle growth, the immune system, and sleep cycles. Notably, GHRP-2 demonstrates oral and sublingual activity, eliminating the necessity for injection to induce its effects.
GHRP-2, also known as pralmorelin, demonstrates a range of effects on the body:
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Protects and Enhances Muscle Structure:
GHRP-2 promotes muscle growth by increasing protein deposition and reducing protein degradation. It has been shown to overcome growth plateaus caused by adverse conditions, such as food deprivation and disease. Additionally, GHRP-2 reduces muscle atrophy by inactivating proteins that control the muscle degradation pathway.
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Stimulates Appetite:
GHRP-2 boosts food intake, which is crucial in addressing appetite stimulation, particularly in chronic disease settings. The ability to reliably stimulate appetite can aid in improving long-term outcomes.
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May Protect the Heart:
Research suggests that GHRP-2 can protect heart cells by reducing programmed cell death (apoptosis), particularly following a heart attack. Identifying specific receptors for these peptides may pave the way for new drug development and enhance our understanding of human physiology.
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Improves the Immune System:
GHRP-2 stimulates the thymus, aiding in the maturation of T cells crucial for adaptive immunity. By rejuvenating the thymus, GHRP-2 enhances the number and diversity of T cells, contributing to improved immunity.
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Improves Sleep Quality:
GHRP-2 has been shown to enhance sleep by increasing the duration of specific sleep cycles, ultimately leading to improvements in cognitive function, blood pressure, healing, and energy levels.
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May Affect Pain Perception:
GHRP-2 exhibits action at opioid receptors, indicating its potential impact on pain perception. As a selective opioid receptor agonist, it may offer pain relief without undesirable side effects like respiratory depression and addiction.
It's essential to note that GHRP-2's use is limited to educational and scientific research.
GHRP-2, or Growth Hormone Releasing Peptide 2, is a synthetic peptide with the chemical structure represented by a sequence of amino acids. Specifically, GHRP-2 is a hexapeptide, consisting of six amino acids arranged in the following sequence:
H-D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2
In this sequence, "H" represents the N-terminus (the starting point), and "NH2" represents the C-terminus (the ending point). Each letter corresponds to a specific amino acid, and the sequence delineates the unique arrangement of these amino acids in the peptide, critical for its biological activity as a growth hormone secretagogue.
