ARA 290

ARA-290 Peptide

ARA-290 peptide, also known as cibinetide and helix B surface peptide (HBSP) in scientific literature, is an 11 amino acid chain derived from the beta domain of the naturally-occurring protein erythropoietin (EPO). This part of the EPO sequence is considered to assist in tissue regeneration and repair without exerting stimulus on the production of red blood cells. Scientists consider the primary function of the EPO is to stimulate tissues to produce red blood cells. Still, the beta domain of the protein, and consequently ARA-290, do not appear to possess this property. Instead, they may possess certain potential regenerative, anti-inflammatory, anti-nociceptive, and other lesser-known properties of the original naturally occurring EPO protein.

Overview

Scientific findings thus far suggest that once a tissue undergoes an injury, a tissue-protective receptor (TPR) pathway may be activated. This TPR receptor mainly consists of a beta receptor unit (CD131) and a subunit from the EPO receptor, jointly called the innate repair receptor. Researchers have suggested that the ARA-290 peptide molecule may bind to this innate repair receptor and possibly attenuate nerve and allodynia-led pain (nociception). It is also suggested that the ARA-290 peptide may act primarily via this IRR-mediated pathway.